distances, full corneal shape and
3-D lens alignment. 3, 4 This is a significant improvement in full in vivo
anterior segment 3-D quantification
with applications that will improve
cataract surgery outcomes. 5
This work was supported by ERC
Advanced Grant 294099 to S. Marcos.
Cataracts cause the crystalline lens of the eye to progressively
lose its transparency, which
decreases vision. It is one of the
major causes of vision loss in our
aging population. Modern cataract
surgery involves the replacement
of the cloudy lens with an intraocular lens (IOL). IOL designs are
becoming more sophisticated, with
benefits such as aspheric surfaces,
multifocality, and the capability to
change position or shape to restore
accomodation. However, optical
(and therefore visual) outcomes are
often limited by the lack of unique
measurements of anatomical ocular
parameters for each individual,
both pre- and post-operatively. In
particular, we rely on the pre-oper-ative ocular biometry to accurately
determine the power of the IOL to
be implanted in a patient. These
biometric measurements could be
dramatically improved by incorporating custom anterior and posterior corneal shape data and more
accurate inter-ocular distances.
We used a laboratory-based spectral optical coherence tomography
(SOCT) instrument with automatic
custom image-processing algorithms
to provide fully quantitative 3-D
biometric data of the anterior
segment of the eye before and after
cataract surgery. 1, 2 While previous
studies provided biometry and IOL
alignment using 1-D low coher-enence interferometry, Purkinje or
Scheimpflug imaging, our study
allowed unbiased high-resolution
measurements of interocular
Biometry and decentration-tilt evaluation from 3-D anterior segment SOCT. (a) Pre-cataract surgery: central corneal thickness (white), anterior chamber depth (red) and
central lens thickness (yellow). (b) Post-cataract surgery with IOL implantation: intraocular lens position (light green), and intraocular lens thickness (orange). (c) Pre-cataract
surgery, and (d) post-cataract surgery with IOL implantation. Vector PW (blue) is the pupillary axis, and LW (purple) is the lens/IOL axis.
Sergio Ortiz ( firstname.lastname@example.org.
csic.es), Pablo Pérez-Merino
and Susana Marcos
IO-CSIC, Madrid, Spain
1. I. Grulkowski et al. Biomed.
Opt. Express 3, 2733 (2012).
2. S. Ortiz et al. Biomed. Opt.
Express 4, 387 (2013).
3. A. de Castro et al. J. Cat.
Refract. Surg. 33, 418 (2007).
4. P. Rosales and S. Marcos. Opt.
Express 15, 2204 (2007).
5. S. Marcos et al. Opthalmol. in
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